Experiences with Diphtheria Toxoid in Canada
نویسندگان
چکیده
منابع مشابه
OPTIMIZATION OF DIPHTHERIA TOXOID PRECIPITATION BY USING SATURATED AMMONIUM SULPHATE IN ORDER TO IMPROVE DIPHTHERIA VACCINE
سابقه و هدف: کورینه باکتریوم دیفتریه باکتری هوازی و بیهوازی اختیاری است. مهمترین گونه از خانواده کورینه باکتریاها، عامل بیماری دیفتری است که به وسیله توکسین خود، بیماری دیفتری را ایجاد میکند. آمونیم سولفات نمکی معدنی است که از آن برای ترسیب و خالصسازی پروتئین ها استفاده میشود که با افزایش مقدار نمک حلالیت پروتئینی کم شده و پروتئین ها به واسطه قطعه های هیدروفوب خود، بههم پیوسته و رسو...
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In Japan, the morbidity rate for pertussis per 100,000 population was 147.6 in 1950 when whole cell pertussis vaccine was introduced but dropped to 0.2 in 1972 when routine immunization with a combined vaccine consisting of diphtheria toxoid, tetanus toxoid, and whole cell pertussis had been widely accepted. Thereafter, adverse reactions to the whole cell pertussis vaccine became a social probl...
متن کاملThe Purification and Concentration of Diphtheria Toxoid
By precipitation with acetone at 4 degrees C. a refined diphtheria toxoid was obtained as a dry powder, readily soluble in aqueous solutions. The powder itself appears to be stable. When dissolved in half the original volume of physiological salt solution, the toxoid remained stable, in the cold room, for a period of 7 months. Only toxoids should be used which have been completely detoxified by...
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Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT. In the first step, following the purification of semi-crude DT by the ion-exchan...
متن کاملAdverse event reports after tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccines in pregnant women.
OBJECTIVE We sought to characterize reports to the Vaccine Adverse Event Reporting System (VAERS) of pregnant women who received tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine (Tdap). STUDY DESIGN We searched VAERS for reports of pregnant women who received Tdap from Jan. 1, 2005, through June 30, 2010. We conducted a clinical review of reports and available medica...
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ژورنال
عنوان ژورنال: American Journal of Public Health and the Nations Health
سال: 1932
ISSN: 0002-9572
DOI: 10.2105/ajph.22.1.25